Leptomeningeal and Intraparenchymal Blood Barrier Disruption in a MOG-IgG-Positive Patient

Seyed Hamidreza Mohseni; Hanne Pernille Bro Skejoe; Jens Wuerfel; Friedemann Paul; Markus Reindl; Sven Jarius; Nasrin Asgari

doi:10.1155/2018/1365175

Leptomeningeal and Intraparenchymal Blood Barrier Disruption in a MOG-IgG-Positive Patient

Seyed Hamidreza Mohseni, Hanne Pernille Bro Skejoe, Jens Wuerfel, Friedemann Paul, Markus Reindl, Sven Jarius, Nasrin Asgari

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Abstract

Background: Recently, pathogenic serum immunoglobulin G (IgG) autoantibodies to myelin oligodendrocyte glycoprotein (MOG) have been detected in a subgroup of patients with central nervous system (CNS) demyelination, including in patients with myelitis. Relatively little is known so far about leptomeningeal involvement in MOG-IgG-positive myelitis.

Findings: We report the case of a 30-year-old previously healthy woman presenting with longitudinally extensive transverse myelitis and tetraparesis, in whom both the leptomeningeal barrier and the blood-brain barrier (BBB) were altered, as demonstrated by gadolinium-enhanced MRI during relapse. Blood samples taken at onset and four years later were retrospectively found positive for MOG-IgG.

Conclusion: Our findings demonstrate that spinal leptomeningeal enhancement (LME) can occur in MOG-IgG-positive encephalomyelitis (EM) and may accompany intraparenchymal BBB breakdown.

Original language	English
Article number	1365175
Journal	Case Reports in Neurological Medicine
Volume	2018
Number of pages	3
ISSN	2090-6668
DOIs	https://doi.org/10.1155/2018/1365175
Publication status	Published - 2018

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Leptomeningeal and Intraparenchymal Blood Barrier Disruption in a MOG-IgG-Positive PatientFinal published version, 1.79 MBLicence: CC BY

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title = "Leptomeningeal and Intraparenchymal Blood Barrier Disruption in a MOG-IgG-Positive Patient",

abstract = "Background: Recently, pathogenic serum immunoglobulin G (IgG) autoantibodies to myelin oligodendrocyte glycoprotein (MOG) have been detected in a subgroup of patients with central nervous system (CNS) demyelination, including in patients with myelitis. Relatively little is known so far about leptomeningeal involvement in MOG-IgG-positive myelitis.Findings: We report the case of a 30-year-old previously healthy woman presenting with longitudinally extensive transverse myelitis and tetraparesis, in whom both the leptomeningeal barrier and the blood-brain barrier (BBB) were altered, as demonstrated by gadolinium-enhanced MRI during relapse. Blood samples taken at onset and four years later were retrospectively found positive for MOG-IgG.Conclusion: Our findings demonstrate that spinal leptomeningeal enhancement (LME) can occur in MOG-IgG-positive encephalomyelitis (EM) and may accompany intraparenchymal BBB breakdown.",

author = "Mohseni, {Seyed Hamidreza} and Skejoe, {Hanne Pernille Bro} and Jens Wuerfel and Friedemann Paul and Markus Reindl and Sven Jarius and Nasrin Asgari",

year = "2018",

doi = "10.1155/2018/1365175",

language = "English",

volume = "2018",

journal = "Case Reports in Neurological Medicine",

issn = "2090-6668",

publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Leptomeningeal and Intraparenchymal Blood Barrier Disruption in a MOG-IgG-Positive Patient

AU - Mohseni, Seyed Hamidreza

AU - Skejoe, Hanne Pernille Bro

AU - Wuerfel, Jens

AU - Paul, Friedemann

AU - Reindl, Markus

AU - Jarius, Sven

AU - Asgari, Nasrin

PY - 2018

Y1 - 2018

N2 - Background: Recently, pathogenic serum immunoglobulin G (IgG) autoantibodies to myelin oligodendrocyte glycoprotein (MOG) have been detected in a subgroup of patients with central nervous system (CNS) demyelination, including in patients with myelitis. Relatively little is known so far about leptomeningeal involvement in MOG-IgG-positive myelitis.Findings: We report the case of a 30-year-old previously healthy woman presenting with longitudinally extensive transverse myelitis and tetraparesis, in whom both the leptomeningeal barrier and the blood-brain barrier (BBB) were altered, as demonstrated by gadolinium-enhanced MRI during relapse. Blood samples taken at onset and four years later were retrospectively found positive for MOG-IgG.Conclusion: Our findings demonstrate that spinal leptomeningeal enhancement (LME) can occur in MOG-IgG-positive encephalomyelitis (EM) and may accompany intraparenchymal BBB breakdown.

AB - Background: Recently, pathogenic serum immunoglobulin G (IgG) autoantibodies to myelin oligodendrocyte glycoprotein (MOG) have been detected in a subgroup of patients with central nervous system (CNS) demyelination, including in patients with myelitis. Relatively little is known so far about leptomeningeal involvement in MOG-IgG-positive myelitis.Findings: We report the case of a 30-year-old previously healthy woman presenting with longitudinally extensive transverse myelitis and tetraparesis, in whom both the leptomeningeal barrier and the blood-brain barrier (BBB) were altered, as demonstrated by gadolinium-enhanced MRI during relapse. Blood samples taken at onset and four years later were retrospectively found positive for MOG-IgG.Conclusion: Our findings demonstrate that spinal leptomeningeal enhancement (LME) can occur in MOG-IgG-positive encephalomyelitis (EM) and may accompany intraparenchymal BBB breakdown.

U2 - 10.1155/2018/1365175

DO - 10.1155/2018/1365175

M3 - Journal article

C2 - 30834146

SN - 2090-6668

VL - 2018

JO - Case Reports in Neurological Medicine

JF - Case Reports in Neurological Medicine

M1 - 1365175

ER -

Leptomeningeal and Intraparenchymal Blood Barrier Disruption in a MOG-IgG-Positive Patient

Abstract

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