Epigenome-wide association study shows that smoking alters DNA methylation in blood cells triggering aggressive bone resorption of osteoclasts in vivo and in vitro

Salah E. Masmoudi; Anaïs Marie Julie Møller; Jonna Skov Madsen; Jean-Marie Delaissé; Bjarne Winther Kristensen; Qihua Tan; Kent Søe

doi:10.1016/j.bonr.2021.100796

Epigenome-wide association study shows that smoking alters DNA methylation in blood cells triggering aggressive bone resorption of osteoclasts in vivo and in vitro

Salah E. Masmoudi, Anaïs Marie Julie Møller, Jonna Skov Madsen, Jean-Marie Delaissé, Bjarne Winther Kristensen, Qihua Tan, Kent Søe^*

^*Corresponding author for this work

University of Southern Denmark

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

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Abstract

Background: Smoking is a risk factor for osteoporosis, but the mechanisms remain unclear. Human osteoclasts can resorb bone in two modes, the aggressive trench-mode and the slower pit-mode. Recently, we have shown1 that e.g. donors’ age correlate with osteoclast trench-mode in vitro suggesting an epigenetic regulation through monocytes.

Original language	English
Article number	100796
Journal	Bone Reports
Volume	14
Issue number	Supplement
Number of pages	1
ISSN	2352-1872
DOIs	https://doi.org/10.1016/j.bonr.2021.100796
Publication status	Published - Apr 2021
Event	ECTS 2021 Digital Congress: ECTS@Home - Online Duration: 19. May 2021 → 20. May 2021

Conference

Conference	ECTS 2021 Digital Congress
Location	Online
Period	19/05/2021 → 20/05/2021

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10.1016/j.bonr.2021.100796Licence: CC BY-NC-ND

Masmoudi et al. 2021 ECTS2021Final published version, 45.9 KBLicence: CC BY-NC-ND

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Masmoudi, S. E., Marie Julie Møller, A., Madsen, J. S., Delaissé, J.-M., Kristensen, B. W., Tan, Q., & Søe, K. (2021). Epigenome-wide association study shows that smoking alters DNA methylation in blood cells triggering aggressive bone resorption of osteoclasts in vivo and in vitro. Bone Reports, 14(Supplement), Article 100796. https://doi.org/10.1016/j.bonr.2021.100796

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title = "Epigenome-wide association study shows that smoking alters DNA methylation in blood cells triggering aggressive bone resorption of osteoclasts in vivo and in vitro",

abstract = "Background: Smoking is a risk factor for osteoporosis, but the mechanisms remain unclear. Human osteoclasts can resorb bone in two modes, the aggressive trench-mode and the slower pit-mode. Recently, we have shown1 that e.g. donors{\textquoteright} age correlate with osteoclast trench-mode in vitro suggesting an epigenetic regulation through monocytes. ",

author = "Masmoudi, {Salah E.} and {Marie Julie M{\o}ller}, Ana{\"i}s and Madsen, {Jonna Skov} and Jean-Marie Delaiss{\'e} and Kristensen, {Bjarne Winther} and Qihua Tan and Kent S{\o}e",

year = "2021",

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doi = "10.1016/j.bonr.2021.100796",

language = "English",

volume = "14",

journal = "Bone Reports",

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Epigenome-wide association study shows that smoking alters DNA methylation in blood cells triggering aggressive bone resorption of osteoclasts in vivo and in vitro. / Masmoudi, Salah E.; Marie Julie Møller, Anaïs; Madsen, Jonna Skov et al.
In: Bone Reports, Vol. 14, No. Supplement, 100796, 04.2021.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

TY - ABST

T1 - Epigenome-wide association study shows that smoking alters DNA methylation in blood cells triggering aggressive bone resorption of osteoclasts in vivo and in vitro

AU - Masmoudi, Salah E.

AU - Marie Julie Møller, Anaïs

AU - Madsen, Jonna Skov

AU - Delaissé, Jean-Marie

AU - Kristensen, Bjarne Winther

AU - Tan, Qihua

AU - Søe, Kent

PY - 2021/4

Y1 - 2021/4

N2 - Background: Smoking is a risk factor for osteoporosis, but the mechanisms remain unclear. Human osteoclasts can resorb bone in two modes, the aggressive trench-mode and the slower pit-mode. Recently, we have shown1 that e.g. donors’ age correlate with osteoclast trench-mode in vitro suggesting an epigenetic regulation through monocytes.

AB - Background: Smoking is a risk factor for osteoporosis, but the mechanisms remain unclear. Human osteoclasts can resorb bone in two modes, the aggressive trench-mode and the slower pit-mode. Recently, we have shown1 that e.g. donors’ age correlate with osteoclast trench-mode in vitro suggesting an epigenetic regulation through monocytes.

U2 - 10.1016/j.bonr.2021.100796

DO - 10.1016/j.bonr.2021.100796

M3 - Conference abstract in journal

SN - 2352-1872

VL - 14

JO - Bone Reports

JF - Bone Reports

IS - Supplement

M1 - 100796

T2 - ECTS 2021 Digital Congress

Y2 - 19 May 2021 through 20 May 2021

ER -

Epigenome-wide association study shows that smoking alters DNA methylation in blood cells triggering aggressive bone resorption of osteoclasts in vivo and in vitro

Abstract

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