GALAXY: Gut-and-liver axis in alcoholic liver fibrosis

2024

Agile Scores in MASLD and ALD: External Validation and Their Utility in Clinical Algorithms

Papatheodoridi, M., De Ledinghen, V., Lupsor-Platon, M., Bronte, F., Boursier, J., Elshaarawy, O., Marra, F., Thiele, M., Markakis, G., Payance, A., Brodkin, E., Castera, L., Papatheodoridis, G., Krag, A., Arena, U., Mueller, S., Cales, P., Calvaruso, V., Delamarre, A. & Pinzani, M. & 1 others, Tsochatzis, E. A., Oct 2024, In: Journal of Hepatology. 81, 4, p. 590-599

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Plasma cathepsin D as an early indicator of alcohol-related liver disease

Li, M., Houben, T., Bitorina, A. V., Meesters, D. M., Israelsen, M., Kjærgaard, M., Koek, G. H., Hendrikx, T., Verbeek, J., Krag, A., Thiele, M. & Shiri-Sverdlov, R., Sept 2024, In: JHEP Reports. 6, 9, 101117.

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2023

Hepatorenal Index by B-Mode Ratio Versus Imaging and Fatty Liver Index to Diagnose Steatosis in Alcohol-Related and Nonalcoholic Fatty Liver Disease

Kjaergaard, M., Lindvig, K. P., Hansen, C. D., Detlefsen, S., Krag, A. & Thiele, M., Feb 2023, In: Journal of Ultrasound in Medicine. 42, 2, p. 487-496

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Sphingolipids Are Depleted in Alcohol-related Liver Fibrosis

Thiele, M., Suvitaival, T., Trošt, K., Kim, M., de Zawadzki, A., Kjaergaard, M., Rasmussen, D. N., Lindvig, K. P., Israelsen, M., Detlefsen, S., Andersen, P., Juel, H. B., Nielsen, T., Georgiou, S., Filippa, V., Kuhn, M., Nishijima, S., Moitinho-Silva, L., Rossing, P. & Trebicka, J. & 7 others, Anastasiadou, E., Bork, P., Hansen, T., Quigley, C. L., Krag, A., MicrobLiver & Galaxy Consortium, Jun 2023, In: Gastroenterology. 164, 7, p. 1248-1260

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2022

High-Throughput UHPLC-MS to Screen Metabolites in Feces for Gut Metabolic Health

Zawadzki, A. D., Thiele, M., Suvitaival, T., Wretlind, A., Kim, M., Ali, M., Bjerre, A. F., Stahr, K., Mattila, I., Hansen, T., Krag, A. & Legido-Quigley, C., Mar 2022, In: Metabolites. 12, 3, 211.

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Metabolic and genetic risk factors are the strongest predictors of severity of alcohol-related liver fibrosis

Israelsen, M., Juel, H. B., Detlefsen, S., Madsen, B. S., Rasmussen, D. N., Larsen, T. R., Kjærgaard, M., Fernandes Jensen, M. J., Stender, S., Hansen, T., Krag, A., Thiele, M. & on behalf of theGALAXY and MicrobLiver consortiak, Aug 2022, In: Clinical Gastroenterology and Hepatology. 20, 8, p. 1784-1794.e9

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Noninvasive proteomic biomarkers for alcohol-related liver disease

Niu, L., Thiele, M., Geyer, P. E., Rasmussen, D. N., Webel, H. E., Santos, A., Gupta, R., Meier, F., Strauss, M., Kjaergaard, M., Lindvig, K., Jacobsen, S., Rasmussen, S., Hansen, T., Krag, A. & Mann, M., Jun 2022, In: Nature Medicine. 28, 6, p. 1277-1287

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Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease

Trebicka, J., Gu, W., de Ledinghen, V., Aubé, C., Krag, A., Praktiknjo, M., Castera, L., Dumortier, J., Bauer, D. J. M., Friedrich-Rust, M., Pol, S., Grgurevic, I., Zheng, R., Francque, S., Gottfriedovà, H., Mustapic, S., Sporea, I., Berzigotti, A., Uschner, F. E. & Simbrunner, B. & 29 others, Ronot, M., Cassinotto, C., Kjaergaard, M., Andrade, F., Schulz, M., Semmler, G., Drinkovic, I. T., Chang, J., Brol, M. J., Rautou, P. E., Vanwolleghem, T., Strassburg, C. P., Boursier, J., Ferstl, P. G., Rasmussen, D. N., Reiberger, T., Vilgrain, V., Guibal, A., Guillaud, O., Zeuzem, S., Vassord, C., Lu, X., Vonghia, L., Senkerikova, R., Popescu, A., Margini, C., Wang, W., Thiele, M. & Jansen, C., Feb 2022, In: Gut. 71, 2, p. 402-414

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2021

A Dynamic Aspartate-to-Alanine Aminotransferase Ratio Provides Valid Predictions of Incident Severe Liver Disease

Åberg, F., Danford, C. J., Thiele, M., Talbäck, M., Rasmussen, D. N., Jiang, Z. G., Hammar, N., Nasr, P., Ekstedt, M., But, A., Puukka, P., Krag, A., Sundvall, J., Erlund, I., Salomaa, V., Stål, P., Kechagias, S., Hultcrantz, R., Lai, M. & Afdhal, N. & 6 others, Jula, A., Männistö, S., Lundqvist, A., Perola, M., Färkkilä, M. & Hagström, H., Jun 2021, In: Hepatology Communications. 5, 6, p. 1021-1035

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AGO2 localizes to cytokinetic protrusions in a p38-dependent manner and is needed for accurate cell division

Pantazopoulou, V. I., Delis, A. D., Georgiou, S., Pagakis, S. N., Filippa, V., Dragona, E., Kloukina, I., Chatzitheodoridis, E., Trebicka, J., Velentzas, A. D., Thiele, M., Gagos, S., Thanos, D., Tseleni-Balafouta, S., Stravopodis, D. J. & Anastasiadou, E., 11. Jun 2021, In: Communications Biology. 4, 1, 18 p., 726.

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Assessment of hepatic steatosis by controlled attenuation parameter using the M and XL probes: an individual patient data meta-analysis

Petroff, D., Blank, V., Newsome, P. N., Shalimar, Voican, C. S., Thiele, M., de Lédinghen, V., Baumeler, S., Chan, W. K., Perlemuter, G., Cardoso, A.-C., Aggarwal, S., Sasso, M., Eddowes, P. J., Allison, M., Tsochatzis, E., Anstee, Q. M., Sheridan, D., Cobbold, J. F. & Naveau, S. & 12 others, Lupsor-Platon, M., Mueller, S., Krag, A., Irles-Depe, M., Semela, D., Wong, G.L.-H., Wong, V.W.-S., Villela-Nogueira, C. A., Garg, H., Chazouillères, O., Wiegand, J. & Karlas, T., Mar 2021, In: The Lancet Gastroenterology & Hepatology. 6, 3, p. 185-198

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Effects of Ethanol Feeding in Early-Stage NAFLD Mice Induced by Western Diet

Brol, M. J., Georgiou, S., Rasmussen, D. N., Ortiz, C., Klein, S., Schierwagen, R., Uschner, F. E., Eberle, L., Detlefsen, S., VASILIKI, I. P., Thiele, M., Filippa, V., SANDRA, T. N., Anastasiadou, E., Krag, A. & Trebicka, J., Feb 2021, In: Livers. 1, 1, p. 27-39

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PRO-C3 and ADAPT algorithm accurately identify patients with advanced fibrosis due to alcohol-related liver disease

Madsen, B. S., Thiele, M., Detlefsen, S., Kjaergaard, M., Møller, L. S., Trebicka, J., Nielsen, M. J., Gudmann, N. S., Leeming, D. J., Karsdal, M. A. & Krag, A., Sept 2021, In: Alimentary Pharmacology & Therapeutics. 54, 5, p. 699-708

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Prognostic performance of 7 biomarkers compared to liver biopsy in early alcohol-related liver disease

Rasmussen, D. N., Thiele, M., Johansen, S., Kjærgaard, M., Lindvig, K. P., Israelsen, M., Antonsen, S., Detlefsen, S., Krag, A., on behalf of the GALAXY MicrobLiver consortia, Hansen, T. (Member of author group), Karsdal, M. (Member of author group) & Trebicka, J. (Member of author group), Nov 2021, In: Journal of Hepatology. 75, 5, p. 1017-1025

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Tidlig opsporing af alkoholrelateret leversygdom

Translated title of the contribution: Early detection of alcohol-related liver diseasePrier Lindvig, K., Krag, A. & Thiele, M., 5. Apr 2021, In: Ugeskrift for Læger. 183, 7A, 3 p., V12200947.

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2020

2D shear wave liver elastography by aixplorer to detect portal hypertension in cirrhosis: an individual patient data meta‐analysis

Thiele, M., Hugger, M. B., Kim, Y., Rautou, P., Elkrief, L., Jansen, C., Verlinden, W., Allegretti, G., Israelsen, M., Stefanescu, H., Piscaglia, F., García‐Pagán, J. C., Franque, S., Berzigotti, A., Castera, L., Jeong, W. K., Trebicka, J. & Krag, A., 1. Jun 2020, In: Liver International. 40, 6, p. 1435-1446

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Cost-effectiveness of non-invasive screening for alcohol-related liver fibrosis

Asphaug, L., Thiele, M., Krag, A., Melberg, H. O. & Galaxy Consortium, Jun 2020, In: Hepatology. 71, 6, p. 2093-2104

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Prediction of liver fibrosis severity in alcoholic liver disease by human microfibrillar-associated protein 4

Madsen, B. S., Thiele, M., Detlefsen, S., Sørensen, M. D., Kjaergaard, M., Sevelsted Møller, L., Nytoft Rasmussen, D., Schlosser, A., Holmskov, U., Trebicka, J., Sorensen, G. L., Krag, A. & Galaxy Consortium, Jul 2020, In: Liver International. 40, 7, p. 1701-1712

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2019

Combination of CCL₄ with alcoholic and metabolic injuries mimics human liver fibrosis

Brol, M. J., Rösch, F., Schierwagen, R., Magdaleno, F., Uschner, F. E., Manekeller, S., Queck, A., Schwarzkopf, K., Odenthal, M., Drebber, U., Thiele, M., Lingohr, P., Plamper, A., Kristiansen, G., Lotersztajn, S., Krag, A., Klein, S., Rheinwalt, K. P. & Trebicka, J., 1. Aug 2019, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 317, 2, p. G182-G194

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2018

Accuracy of the Enhanced Liver Fibrosis Test vs Fibrotest, Elastography and Indirect Markers in Detection of Advanced Fibrosis in Patients with Alcoholic Liver Disease

Thiele, M., Madsen, B. S., Hansen, J. F., Detlefsen, S., Antonsen, S. & Krag, A., Apr 2018, In: Gastroenterology. 154, 5, p. 1369-1379

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Controlled Attenuation Parameter And Alcoholic Hepatic Steatosis: Diagnostic Accuracy and Role Of Alcohol Detoxification

Thiele, M., Rausch, V., Fluhr, G., Kjærgaard, M., Piecha, F., Mueller, J., Straub, B. K., Lupşor-Platon, M., De-Ledinghen, V., Seitz, H. K., Detlefsen, S., Madsen, B., Krag, A. & Mueller, S., May 2018, In: Journal of Hepatology. 68, 5, p. 1025-1032

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GALAXY: Gut-and-liver axis in alcoholic liver fibrosis

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