Martin Brandl

2024

Melt-extruded formulations of fenofibrate with various grades of hydrogenated phospholipid exhibit promising in-vitro biopharmaceutical behavior

Czajkowski, M., Słaba, A., Milanowski, B., Bauer-Brandl, A., Brandl, M. & Skupin-Mrugalska, P., 1. Dec 2024, In: European Journal of Pharmaceutical Sciences. 203, 14 p., 106936.

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Oral absorption from surfactant-based drug formulations: the impact of molecularly dissolved drug on bioavailability

Holzem, F. L., Parrott, N., Schaffland, J. P., Brandl, M., Bauer-Brandl, A. & Stillhart, C., Oct 2024, In: Journal of Pharmaceutical Sciences. 113, 10, p. 3054-3064

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Using molecularly dissolved drug concentrations in PBBMs improves the prediction of oral absorption from supersaturating formulations

Holzem, F. L., Petrig Schaffland, J., Brandl, M., Bauer-Brandl, A. & Stillhart, C., 1. Mar 2024, In: European Journal of Pharmaceutical Sciences. 194, 13 p., 106703.

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2023

Combining in vitro dissolution/permeation with microdialysis sampling: Capabilities and limitations for biopharmaceutical assessments of supersaturating drug formulations

Holzem, F. L., Jensen, I. H., Petrig Schaffland, J., Stillhart, C., Brandl, M. & Bauer-Brandl, A., 1. Sept 2023, In: European Journal of Pharmaceutical Sciences. 188, 9 p., 106533.

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Drug Dissolution in Oral Drug Absorption: Workshop Report

Raines, K., Agarwal, P., Augustijns, P., Alayoubi, A., Attia, L., Bauer-Brandl, A., Brandl, M., Chatterjee, P., Chen, H., Yu, Y. C., Coutant, C., Coutinho, A. L., Curran, D., Dressman, J., Ericksen, B., Falade, L., Gao, Y., Gao, Z., Ghosh, D. & Ghosh, T. & 26 others, Govada, A., Gray, E., Guo, R., Hammell, D., Hermans, A., Jaini, R., Li, H., Mandula, H., Men, S., Milsmann, J., Moldthan, H., Moody, R., Moseson, D. E., Müllertz, A., Patel, R., Paudel, K., Reppas, C., Savkur, R., Schaefer, K., Serajuddin, A., Taylor, L. S., Valapil, R., Wei, K., Weitschies, W., Yamashita, S. & Polli, J. E., Nov 2023, In: The AAPS Journal. 25, 6, p. 103 20 p.

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Hydrogenated phospholipid, a promising excipient in amorphous solid dispersions of fenofibrate for oral delivery: Preparation and in-vitro biopharmaceutical characterization

Czajkowski, M., Jacobsen, A. C., Bauer-Brandl, A., Brandl, M. & Skupin-Mrugalska, P., 25. Sept 2023, In: International Journal of Pharmaceutics. 644, 123294.

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Impact of prandial state on luminal and permeation-behavior of fosamprenavir oral suspension studied by in vitro tools: Solubility-, bioconversion- and permeation- studies in biomimetic media

Eriksen, J. B., Azimi, Z., Milsmann, J., Bauer-Brandl, A. & Brandl, M., Dec 2023, In: Journal of Drug Delivery Science and Technology. 90, 105170.

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Insight into the mechanism behind oral bioavailability-enhancement by nanosuspensions through combined dissolution/permeation studies

Lynnerup, J. T., Eriksen, J. B., Bauer-Brandl, A., Holsæter, A. M. & Brandl, M., Mar 2023, In: European Journal of Pharmaceutical Sciences. 184, 106417.

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Interaction of liposomes with bile salts investigated by asymmetric flow field-flow fractionation (AF4): A novel approach for stability assessment of oral drug carriers

Bohsen, M. S., Tychsen, S. T., Kadhim, A. A. H., Grohganz, H., Treusch, A. H. & Brandl, M., 1. Mar 2023, In: European Journal of Pharmaceutical Sciences. 182, p. 106384 10 p.

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In vitro Dissolution/Permeation tools for amorphous solid dispersions bioavailability forecasting I: Experimental design for PermeaLoop™

Nunes, P. D., Pinto, J. F., Bauer-Brandl, A., Brandl, M., Henriques, J. & Paiva, A. M., 1. Sept 2023, In: European Journal of Pharmaceutical Sciences. 188, 11 p., 106512.

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In vitro Dissolution/Permeation tools for amorphous solid dispersions bioavailability forecasting II: Comparison and mechanistic insights

Nunes, P. D., Ferreira, A. F., Pinto, J. F., Bauer-Brandl, A., Brandl, M., Henriques, J. & Paiva, A. M., Sept 2023, In: European Journal of Pharmaceutical Sciences. 188, 17 p., 106513.

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In-vitro dynamic dissolution/bioconversion/permeation of fosamprenavir using a novel tool with an artificial biomimetic permeation barrier and microdialysis-sampling

Eriksen, J. B., Christiansen, J. J., Bauer-Brandl, A., Ruponen, M., Rautio, J. & Brandl, M., 1. Feb 2023, In: European Journal of Pharmaceutical Sciences. 181, 106366.

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When interactions between bile salts and cyclodextrin cause a negative food effect: Dynamic dissolution/permeation studies with itraconazole (Sporanox®) and biomimetic media

Cuoco, A., Eriksen, J. B., Luppi, B., Brandl, M. & Bauer-Brandl, A., May 2023, In: Journal of Pharmaceutical Sciences. 112, 5, p. 1372-1378

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2022

`Stirred not shaken!' Comparing agitation methods for permeability studies using a novel type of 96-well sandwich-plates

Eriksen, J. B., Jacobsen, A.-C., Christensen, K. T., Bauer-Brandl, A. & Brandl, M., Jan 2022, In: Journal of Pharmaceutical Sciences. 111, 1, p. 32-40

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Best practices in current models mimicking drug permeability in the gastrointestinal tract - an UNGAP review

O'Shea, J. P., Augustijns, P., Brandl, M., Brayden, D. J., Brouwers, J., Griffin, B. T., Holm, R., Jacobsen, A.-C., Lennernäs, H., Vinarov, Z. & O'Driscoll, C. M., 1. Mar 2022, In: European Journal of Pharmaceutical Sciences. 170, p. 106098 35 p., 106098.

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Biopredictive capability assessment of two dissolution/permeation assays, µFLUX™ and PermeaLoop™, using supersaturating formulations of Posaconazole

Holzem, F. L., Weck, A., Schaffland, J. P., Stillhart, C., Klein, S., Bauer-Brandl, A. & Brandl, M., 1. Sept 2022, In: European Journal of Pharmaceutical Sciences. 176, 106260.

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Dissolution/permeation of albendazole in the presence of cyclodextrin and bile salts: a mechanistic in vitro study into factors governing oral bioavailability

Eriksen, J. B., Christensen, S. B., Bauer-Brandl, A. & Brandl, M., Jun 2022, In: Journal of Pharmaceutical Sciences. 111, 6, p. 1667-1673

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How docetaxel entrapment, vesicle size, zeta potential and stability change with liposome composition–A formulation screening study

Holsæter, A. M., Wizgird, K., Karlsen, I., Hemmingsen, J. F., Brandl, M. & Škalko-Basnet, N., Oct 2022, In: European Journal of Pharmaceutical Sciences. 177, 106267.

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Microdialysis and nanofiltration allow to distinguish molecularly dissolved from colloid- associated drug concentrations during biomimetic dissolution testing of supersaturating formulations

Holzem, F. L., Schaffland, J. P., Brandl, M., Bauer-Brandl, A. & Stillhart, C., 1. Jul 2022, In: European Journal of Pharmaceutical Sciences. 174, 106166.

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Modulation of paracellular-like drug transport an artificial biomimetic barrier by osmotic stress-induced liposome shrinking

Eriksen, J. B., Barakat, H., Luppi, B., Brandl, M. & Bauer-Brandl, A., Apr 2022, In: Pharmaceutics. 14, 4, 9 p., 721.

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2021

Application of Asymmetrical Flow Field-Flow Fractionation for Characterizing the Size and Drug Release Kinetics of Theranostic Lipid Nanovesicles

Skupin-Mrugalska, P., Elvang, P. A. & Brandl, M., 28. Sept 2021, In: International Journal of Molecular Sciences . 22, 19, 20 p., 10456.

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Do Phospholipids Boost or Attenuate Drug Absorption? In Vitro and In Vivo Evaluation of Mono- and Diacyl Phospholipid-Based Solid Dispersions of Celecoxib

Jacobsen, A. C., Ejskjær, L., Brandl, M., Holm, R. & Bauer-Brandl, A., Jan 2021, In: Journal of Pharmaceutical Sciences. 110, 1, p. 198-207

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Identification and quantification of glucose degradation products in heat-sterilized glucose solutions for parenteral use by thin-layer chromatography

Leitzen, S., Vogel, M., Engels, A., Zapf, T. & Brandl, M., Jul 2021, In: PLOS ONE. 16, 7, 22 p., e0253811.

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Quantification of degradation products formed during heat sterilization of glucose solutions by lc-ms/ms: Impact of autoclaving temperature and duration on degradation

Leitzen, S., Vogel, M., Steffens, M., Zapf, T., Müller, C. E. & Brandl, M., Nov 2021, In: Pharmaceuticals. 14, 11, 1121.

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2020

(Sub)micron particles forming in aqueous dispersions of amorphous solid dispersions of the poorly soluble drug ABT-199: A combined particle optical counting and field-flow fractionation study

Bohsen, M. S., Elvang, P. A., Reder-Hilz, B., Lenz, V., Rosenberg, J. & Brandl, M., 1. Nov 2020, In: European Journal of Pharmaceutical Sciences. 154, 10 p., 105497.

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Dissolution/permeation with PermeaLoop™: Experience and IVIVC exemplified by dipyridamole enabling formulations

Eriksen, J. B., Messerschmid, R., Andersen, M. L., Wada, K., Bauer-Brandl, A. & Brandl, M., 1. Nov 2020, In: European Journal of Pharmaceutical Sciences. 154, 12 p., 105532.

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Drug Permeability Profiling Using the Novel Permeapad® 96-Well Plate

Jacobsen, A. C., Nielsen, S., Brandl, M. & Bauer-Brandl, A., 2020, In: Pharmaceutical Research. 37, 6, 15 p., 93.

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Exploring impact of supersaturated lipid-based drug delivery systems of celecoxib on in vitro permeation across PermeapadⓇ membrane and in vivo absorption

Ilie, A.-R., Griffin, B. T., Brandl, M., Bauer-Brandl, A., Jacobsen, A.-C., Vertzoni, M., Kuentz, M., Kolakovic, R. & Holm, R., Sept 2020, In: European Journal of Pharmaceutical Sciences. 152, 11 p., 105452.

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The Influence of Liquid Intake on the Performance of an Amorphous Solid Dispersion in Rats

Sironi, D., Bauer-Brandl, A., Brandl, M., Rosenberg, J. & Fricker, G., Jul 2020, In: European Journal of Pharmaceutics and Biopharmaceutics. 152, p. 296-298

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2019

A dynamic in vitro permeation study on solid mono- and diacyl-phospholipid dispersions of celecoxib

Jacobsen, A.-C., Elvang, P. A., Bauer-Brandl, A. & Brandl, M., 15. Jan 2019, In: European Journal of Pharmaceutical Sciences. 127, p. 199-207

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Co-existing colloidal phases of human duodenal aspirates: Intraindividual fluctuations and interindividual variability in relation to molecular composition

Elvang, P. A., Bohsen, M. S., Stein, P. C., Bauer-Brandl, A., Riethorst, D., Brouwers, J., Augustijns, P. & Brandl, M., 5. Jun 2019, In: Journal of Pharmaceutical and Biomedical Analysis. 170, June, p. 22-29

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High-Throughput Dissolution/Permeation Screening -A 96-Well Two-Compartment Microplate Approach

Jacobsen, A.-C., Krupa, A., Brandl, M. & Bauer-Brandl, A., 10. May 2019, In: Pharmaceutics. 11, 5, p. 227

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Oromucosal drug delivery: Trends in in-vitro biopharmaceutical assessment of new chemical entities and formulations

Brandl, M. & Bauer-Brandl, A., 1. Feb 2019, In: European Journal of Pharmaceutical Sciences. 128, 1, p. 112-117

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Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

Boyd, B. J., Bergström, C. A. S., Vinarov, Z., Kuentz, M., Brouwers, J., Augustijns, P., Brandl, M., Bernkop-Schnürch, A., Shrestha, N., Préat, V., Müllertz, A., Bauer-Brandl, A. & Jannin, V., Sept 2019, In: European Journal of Pharmaceutical Sciences. 137, 27 p., 104967.

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2018

Co-existing colloidal phases in artificial intestinal fluids assessed by AF4/MALLS and DLS: A systematic study into cholate & (lyso-) phospholipid blends, incorporating celecoxib as a model drug

Elvang, P. A., Jacobsen, A. C., Bauer-Brandl, A., Stein, P. C. & Brandl, M., 2018, In: European Journal of Pharmaceutical Sciences. 120, p. 61-72

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Drug permeability profiling using cell-free permeation tools: Overview and applications

Berben, P., Bauer-Brandl, A., Brandl, M., Faller, B., Flaten, G. E., Jacobsen, A.-C., Brouwers, J. & Augustijns, P., 2018, In: European Journal of Pharmaceutical Sciences. 119, p. 219-233

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PermeaLoop™, a novel in vitro tool for small-scale drug-dissolution/permeation studies

Sironi, D., Rosenberg, J., Bauer-Brandl, A. & Brandl, M., 2018, In: Journal of Pharmaceutical and Biomedical Analysis. 156, 15 July, p. 247-251

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2017

Archaeal lipids in oral delivery of therapeutic peptides

Jacobsen, A.-C., Jensen, S. M., Fricker, G., Brandl, M. & Treusch, A. H., 2017, In: European Journal of Pharmaceutical Sciences. 108, p. 101-110

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Characterization of co-existing colloidal structures in fasted state simulated fluids FaSSIF: A comparative study using AF4/MALLS, DLS and DOSY

Elvang, P. A., Stein, P. C., Bauer-Brandl, A. & Brandl, M., 2017, In: Journal of Pharmaceutical and Biomedical Analysis. 145, p. 531-536

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Dynamic dissolution-/permeation-testing of nano- and microparticle formulations of fenofibrate

Sironi, D., Rosenberg, J., Bauer-Brandl, A. & Brandl, M., 2017, In: European Journal of Pharmaceutical Sciences. 96, p. 20-27

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Evaluation of a dynamic dissolution/permeation model: Mutual influence of dissolution and barrier-flux under non-steady state conditions

Sironi, D., Christensen, M., Rosenberg, J., Bauer-Brandl, A. & Brandl, M., 2017, In: International Journal of Pharmaceutics. 522, 1-2, p. 50-57

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Oral bioavailability enhancement through supersaturation: an update and meta-analysis

Fong, S. Y. K., Bauer-Brandl, A. & Brandl, M., Mar 2017, In: Expert Opinion on Drug Delivery. 14, 3, p. 403-426

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Surfactants enhance recovery of poorly soluble drugs during microdialysis sampling: Implications for in vitro dissolution-/permeation-studies

Koplin, S., Kumpugdee-Vollrath, M., Bauer-Brandl, A. & Brandl, M., 2017, In: Journal of Pharmaceutical and Biomedical Analysis. 145, p. 586-592

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2016

A new approach for a blood-brain barrier model based on phospholipid vesicles: Membrane development and siRNA-loaded nanoparticles permeability

Gomes, M. J., Dreier, J., Brewer, J., Martins, S., Brandl, M. & Sarmento, B., 1. Apr 2016, In: Journal of Membrane Science. 503, p. 8-15

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A novel microdialysis-dissolution/permeation system for testing oral dosage forms: A proof-of-concept study

Fong, S. Y. K., Poulsen, J., Brandl, M. & Bauer-Brandl, A., 2016, In: European Journal of Pharmaceutical Sciences. 96, 1, p. 154-163

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Bile Salt Micelles and Phospholipid Vesicles Present in Simulated and Human Intestinal Fluids: Structural Analysis by Flow Field-Flow Fractionation/Multiangle Laser Light Scattering

Elvang, P. A., Hinna, A. H., Brouwers, J., Hens, B., Augustijns, P. & Brandl, M., 2016, In: Journal of Pharmaceutical Sciences. 105, 9, p. 2832-2839

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Filter-extruded liposomes revisited: a study into size distributions and morphologies in relation to lipid-composition and process parameters

Hinna, A., Steiniger, F., Hupfeld, S., Stein, P. C., Kuntsche, J. & Brandl, M., 2016, In: Journal of Liposome Research. 26, 1, p. 11-20

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Mechanism and kinetics of the loss of poorly soluble drugs from liposomal carriers studied by a novel flow field-flow fractionation-based drug release-/transfer-assay

Hinna, A. H., Hupfeld, S., Kuntsche, J., Bauer-Brandl, A. & Brandl, M., 2016, In: Journal of Controlled Release. 232, p. 228-237

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Solid Phospholipid Dispersions for Oral Delivery of Poorly Soluble Drugs: Investigation into Celecoxib Incorporation and Solubility-In Vitro Permeability Enhancement

Fong, S. Y. K., Martins, S. A. M., Brandl, M. & Bauer-Brandl, A., 2016, In: Journal of Pharmaceutical Sciences. 105, 3, p. 1113-1123

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The use of asymmetrical flow field-flow fractionation with on-line detection in the study of drug retention within liposomal nanocarriers and drug transfer kinetics

Hinna, A. H., Hupfeld, S., Kuntsche, J. & Brandl, M., 2016, In: Journal of Pharmaceutical and Biomedical Analysis. 124, p. 157-163

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Martin Brandl

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