MYC activates transcriptional enhancers to drive cancer progression

Rasmus Siersbæk; Simon Toftholm Jakobsen

doi:10.1038/s41588-024-01677-y

MYC activates transcriptional enhancers to drive cancer progression

Rasmus Siersbæk, Simon Toftholm Jakobsen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Formidling

Abstract

We show that in addition to promoter activation, MYC drives cancer progression by activating transcriptional enhancers via a distinct mechanism. MYC cooperates with several other proteins at these cis-regulatory regions to change the epigenome and promote recruitment of RNA polymerase II and enhancer transcription.

Originalsprog	Engelsk
Tidsskrift	Nature Genetics
Vol/bind	56
Udgave nummer	4
Sider (fra-til)	567-568
ISSN	1061-4036
DOI	https://doi.org/10.1038/s41588-024-01677-y
Status	Udgivet - apr. 2024

Dokumenter og links

10.1038/s41588-024-01677-y

Citationsformater

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title = "MYC activates transcriptional enhancers to drive cancer progression",

abstract = "We show that in addition to promoter activation, MYC drives cancer progression by activating transcriptional enhancers via a distinct mechanism. MYC cooperates with several other proteins at these cis-regulatory regions to change the epigenome and promote recruitment of RNA polymerase II and enhancer transcription.",

keywords = "Humans, Cell Line, Tumor, Enhancer Elements, Genetic/genetics, Genes, myc, Neoplasms/genetics, Proto-Oncogene Proteins c-myc/genetics, Regulatory Sequences, Nucleic Acid",

author = "Rasmus Siersb{\ae}k and Jakobsen, {Simon Toftholm}",

year = "2024",

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doi = "10.1038/s41588-024-01677-y",

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T1 - MYC activates transcriptional enhancers to drive cancer progression

AU - Siersbæk, Rasmus

AU - Jakobsen, Simon Toftholm

PY - 2024/4

Y1 - 2024/4

N2 - We show that in addition to promoter activation, MYC drives cancer progression by activating transcriptional enhancers via a distinct mechanism. MYC cooperates with several other proteins at these cis-regulatory regions to change the epigenome and promote recruitment of RNA polymerase II and enhancer transcription.

AB - We show that in addition to promoter activation, MYC drives cancer progression by activating transcriptional enhancers via a distinct mechanism. MYC cooperates with several other proteins at these cis-regulatory regions to change the epigenome and promote recruitment of RNA polymerase II and enhancer transcription.

KW - Humans

KW - Cell Line, Tumor

KW - Enhancer Elements, Genetic/genetics

KW - Genes, myc

KW - Neoplasms/genetics

KW - Proto-Oncogene Proteins c-myc/genetics

KW - Regulatory Sequences, Nucleic Acid

U2 - 10.1038/s41588-024-01677-y

DO - 10.1038/s41588-024-01677-y

M3 - Journal article

C2 - 38480925

SN - 1061-4036

VL - 56

SP - 567

EP - 568

JO - Nature Genetics

JF - Nature Genetics

IS - 4

ER -

MYC activates transcriptional enhancers to drive cancer progression

Abstract

Dokumenter og links

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Citationsformater