Mitochondria–A target for attenuation of astrocyte pathology

Marlene Thorsen Morch; Reza Khorooshi; Joanna Marczynska; Magdalena Dubik; Soeren Nielsen; John Dirk Nieland; Nasrin Asgari; Trevor Owens

doi:10.1016/j.jneuroim.2021.577657

Mitochondria–A target for attenuation of astrocyte pathology

Marlene Thorsen Morch, Reza Khorooshi, Joanna Marczynska, Magdalena Dubik, Soeren Nielsen, John Dirk Nieland, Nasrin Asgari, Trevor Owens^*

^*Kontaktforfatter

KI, BRIDGE - Brain Research - Inter Disciplinary Guided Excellence (Odense)
IRS - Næstved, Slagelse, Ringsted Sygehuse (NSR), Forskningsenhed for Neurologi (Slagelse)

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

Astrocyte pathology is a feature of neuromyelitis optica spectrum disorder (NMOSD) pathology. Recently mitochondrial dysfunction and metabolic changes were suggested to play a role in NMOSD. To elucidate the role of mitochondrial dysfunction, astrocyte pathology was induced in C57BL/6 J female mice by intracerebral injection of aquaporin-4-immunoglobulin G from an NMOSD patient, together with complement. Etomoxir has been shown to cause mitochondrial dysfunction. Etomoxir was delivered to the central nervous system and resulted in decreased astrocyte pathology. The ameliorating effect was associated with increases in different acylcarnitines and amino acids. This suggests that mitochondria may be a therapeutic target in NMOSD.

Originalsprog	Engelsk
Artikelnummer	577657
Tidsskrift	Journal of Neuroimmunology
Vol/bind	358
Antal sider	5
ISSN	0165-5728
DOI	https://doi.org/10.1016/j.jneuroim.2021.577657
Status	Udgivet - 15. sep. 2021

Bibliografisk note

Funding Information:
This research was supported by the Danish Multiple Sclerosis Society ; The Lundbeck Foundation (# R198-2015-171 ); Ph.D. stipends from The University of Southern Denmark, Health Sciences Faculty; Warwara Larsens Fond; Bjarne Jensens Fond; Augustinus Foundation; Lægefonden; Dagmar Marshalls Fond and Familien Hede Nielsens Fond.

Publisher Copyright:
© 2021 The Authors

Dokumenter og links

10.1016/j.jneuroim.2021.577657Licens: CC BY

Open Access VersionForlagets udgivne version, 1,06 MBLicens: CC BY

Citationsformater

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title = "Mitochondria–A target for attenuation of astrocyte pathology",

abstract = "Astrocyte pathology is a feature of neuromyelitis optica spectrum disorder (NMOSD) pathology. Recently mitochondrial dysfunction and metabolic changes were suggested to play a role in NMOSD. To elucidate the role of mitochondrial dysfunction, astrocyte pathology was induced in C57BL/6 J female mice by intracerebral injection of aquaporin-4-immunoglobulin G from an NMOSD patient, together with complement. Etomoxir has been shown to cause mitochondrial dysfunction. Etomoxir was delivered to the central nervous system and resulted in decreased astrocyte pathology. The ameliorating effect was associated with increases in different acylcarnitines and amino acids. This suggests that mitochondria may be a therapeutic target in NMOSD.",

keywords = "Astrocyte pathology, Central nervous system, Etomoxir, Metabolic, Mitochondrial dysfunction, Neuromyelitis optica spectrum disorder",

author = "Morch, {Marlene Thorsen} and Reza Khorooshi and Joanna Marczynska and Magdalena Dubik and Soeren Nielsen and Nieland, {John Dirk} and Nasrin Asgari and Trevor Owens",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = sep,

day = "15",

doi = "10.1016/j.jneuroim.2021.577657",

language = "English",

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TY - JOUR

T1 - Mitochondria–A target for attenuation of astrocyte pathology

AU - Morch, Marlene Thorsen

AU - Khorooshi, Reza

AU - Marczynska, Joanna

AU - Dubik, Magdalena

AU - Nielsen, Soeren

AU - Nieland, John Dirk

AU - Asgari, Nasrin

AU - Owens, Trevor

PY - 2021/9/15

Y1 - 2021/9/15

N2 - Astrocyte pathology is a feature of neuromyelitis optica spectrum disorder (NMOSD) pathology. Recently mitochondrial dysfunction and metabolic changes were suggested to play a role in NMOSD. To elucidate the role of mitochondrial dysfunction, astrocyte pathology was induced in C57BL/6 J female mice by intracerebral injection of aquaporin-4-immunoglobulin G from an NMOSD patient, together with complement. Etomoxir has been shown to cause mitochondrial dysfunction. Etomoxir was delivered to the central nervous system and resulted in decreased astrocyte pathology. The ameliorating effect was associated with increases in different acylcarnitines and amino acids. This suggests that mitochondria may be a therapeutic target in NMOSD.

AB - Astrocyte pathology is a feature of neuromyelitis optica spectrum disorder (NMOSD) pathology. Recently mitochondrial dysfunction and metabolic changes were suggested to play a role in NMOSD. To elucidate the role of mitochondrial dysfunction, astrocyte pathology was induced in C57BL/6 J female mice by intracerebral injection of aquaporin-4-immunoglobulin G from an NMOSD patient, together with complement. Etomoxir has been shown to cause mitochondrial dysfunction. Etomoxir was delivered to the central nervous system and resulted in decreased astrocyte pathology. The ameliorating effect was associated with increases in different acylcarnitines and amino acids. This suggests that mitochondria may be a therapeutic target in NMOSD.

KW - Astrocyte pathology

KW - Central nervous system

KW - Etomoxir

KW - Metabolic

KW - Mitochondrial dysfunction

KW - Neuromyelitis optica spectrum disorder

U2 - 10.1016/j.jneuroim.2021.577657

DO - 10.1016/j.jneuroim.2021.577657

M3 - Journal article

C2 - 34315069

AN - SCOPUS:85111003760

SN - 0165-5728

VL - 358

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

M1 - 577657

ER -

Mitochondria–A target for attenuation of astrocyte pathology

Abstract

Bibliografisk note

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