Abstract
Objectives: This study aims to evaluate matrix metalloproteinase-7 as a first trimester biomarker for late-onset preeclampsia, both alone and in combination with mean arterial pressure, uterine artery pulsatility index, and maternal characteristics. Study design: We conducted a nested case-control study from a prospective cohort consisting of 416 pregnant women who attended a routine first trimester scan. Baseline variables were obtained at inclusion and analysed subsequently to formation of case and control groups. The study was designed to detect a mean difference of > 15% in matrix metalloproteinase-7 concentrations between groups with a statistical power of 80%. Main outcome measures: The primary outcome was preeclampsia with delivery after 34 weeks of pregnancy. Results: The median matrix metalloproteinase-7 concentration in cases of late-onset preeclampsia (n = 27) was marginally lower compared to normotensive controls but this difference was not statistically significant. Matrix metalloproteinase-7 predicted 14.8% of cases at a 10% false-positive rate. Addition of matrix metalloproteinase-7 to any combination of variables did not significantly improve their performance. Conclusions: Matrix metalloproteinase-7 is not a useful biomarker for late-onset preeclampsia, neither alone nor in combination with mean arterial pressure, uterine artery pulsatility index, or maternal characteristics.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Pregnancy Hypertension |
| Vol/bind | 28 |
| Sider (fra-til) | 94-99 |
| ISSN | 2210-7789 |
| DOI | |
| Status | Udgivet - jun. 2022 |
Bibliografisk note
Funding Information:This research project was conducted with the support of OPEN, Open Patient data Explorative Network, Odense University Hospital, Region of Southern Denmark, namely OPEN Biobank and OPEN Statistics. Study data were collected and managed using REDCap (Research Electronic Data Capture) tools hosted at Region Syddanmark. We thank the sonographers at the Department of Obstetrics and Gynecology for performing all uterine artery Doppler measurements for this study, and Christian Enggaard and Niels Str?mvig Larsen at the Department of Clinical Biochemistry for excellent technical laboratory assistance. This work was supported by the OUH Free Research Fund (72-A3727), which had no involvement in its conduction or subsequent publication. Julie Dahl Ravn: I declare that I participated in data collection, data analysis, and writing of this article and that I have seen and approved the final version. I have the following conflicts of interest: none. Emma Julie Bendix: I declare that I participated in data collection for this article and that I have seen and approved the final version. I have the following conflicts of interest: none. Lene Sperling: I declare that I participated in designing this study and oversaw its supervision and that I have seen and approved the final version. I have the following conflicts of interest: none. Martin Overgaard: I declare that I participated in designing this study, application for funding, supervision, and participated in data analysis for this article and that I have seen and approved the final version. I have the following conflicts of interest: none.
Funding Information:
This work was supported by the OUH Free Research Fund (72-A3727), which had no involvement in its conduction or subsequent publication.