Clinical Significance, Species Distribution, and Temporal Trends of Nontuberculous Mycobacteria, Denmark, 1991–2022

Victor Naestholt Dahl*, Andreas Arnholdt Pedersen, Anders Norman, E. Michael Rasmussen, Jakko van Ingen, Aase Bengaard Andersen, Christian Morberg Wejse, Troels Lillebaek

*Kontaktforfatter

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

Nontuberculous mycobacteria (NTM) are emerging as notable causative agents of opportunistic infections. To examine clinical significance, species distribution, and temporal trends of NTM in Denmark, we performed a nationwide register-based study of all unique persons with NTM isolated in the country during 1991–2022. We categorized patients as having definite disease, possible disease, or isolation by using a previously validated method. The incidence of pulmonary NTM increased throughout the study period, in contrast to earlier findings. Mycobacterium malmoense, M. kansasii, M. szulgai, and M. avium complex were the most clinically significant species based on microbiologic findings; M. avium dominated in incidence. This study shows the need for surveillance for an emerging infection that is not notifiable in most countries, provides evidence to support clinical decision-making, and highlights the importance of not considering NTM as a single entity.

OriginalsprogEngelsk
TidsskriftEmerging Infectious Diseases
Vol/bind30
Udgave nummer9
Sider (fra-til)1755-1762
ISSN1080-6040
DOI
StatusUdgivet - 1. sep. 2024

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